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Job Details

Immuno-Oncology Scientist

Company name
Second Genome

South San Francisco, CA

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Job Location(s):

South San Francisco, CA, US


Hi, we’re Second Genome.

We are a fast-paced and innovative venture-backed biotechnology company seeking tomorrow’s breakthrough therapeutics at the interface of complex microbial communities and their host environments. We are leaders in microbial ecology, metagenomics, and computer science. We love fresh approaches, we value process validation, and we welcome peer review.

In addition to our ground-breaking technology, we believe in embodying an authentically joyful workplace. Our Core Values:

We are Innovators

We are Driven to Action

We are Great Colleagues

We Work Smart

We Respect the Data

And we’re looking for an Immuno-Oncology Scientist to join our team.

We’re on the search for an IO Scientist with a passion for tackling new challenges. We’d love to work with someone who is personally driven but comfortable not having all the answers; resourceful when working toward goals; accepting of the changing demands of the industry environment, and a natural multi-tasker. Our candidate has a PhD degree (or equivalent) with 1-3 years of relevant postdoctoral experience in immunology, oncology, cancer biology and/or related disciplines. We deeply value team players who understand the importance of communication and the balance between compromise and assertion.

Responsibilities and Duties

Assume role as a research expert to drive drug discovery and novel translational research focused on leveraging the microbiome’s influence on tumor immunology

Design, prioritize, and execute appropriate functional assays

Develop and implement novel experimental protocols

Communicate findings and interpretation of results both internally and externally

As part of a research team, define project objectives and prioritize experiments accordingly

Qualifications and Skills

Deep knowledge and expertise in immunology or oncology, with proven contributions to research in the field of immune-cell metabolism and/or immune effector functions in the tumor microenvironment

Strong background and hands-on experience in the design and interpretation of in vitro and in vivo experimental models that include, but are not limited to

rodent and human primary cell-based assays;

explant culture systems;

3D organoid systems and/or

pre-clinical animal tumor models

Experience with routine laboratory analysis methods, including PCR, ELISA, Western blotting, FACS, RNA-seq, etc.

Strong written and oral communication skills

Ability to thrive in a cross-functional, collaborative research environment

Ability to support multiple projects and meet ambitious goals and timelines

Bonus Qualifications

Scientific know-how of, or demonstrated interest in, stromal-immune cell interactions in the tumor microenvironment

Experience with human tissue-based models

Experience with (in vitro and in vivo) pharmacology, target assessment and translational biomarkers

Analysis and interpretation of microbe-host interactions, particularly microbial regulators of the host immune response

What’s it like to work at Second Genome?

We understand and appreciate the hard work and emotional investment on the part of all our team members - it takes a lot to be a contributor at a startup that’s leading its industry. We make it a priority to mindfully design our work environment and employee offerings with our unique and dedicated team in mind.

Competitive salary and employee stock options.

Fully stocked kitchen with sandwich materials, organic snacks, coffee (Peet’s or Stumptown - take your pick!) and beverages.

Four weeks paid time off, plus federal holidays.

Generous and comprehensive medical, dental, and vision plan options, including doctor house calls and in-office clinics.

401(k) plan, HSA option, and pre-tax FSA accounts: dependent care, transit, healthcare, and parking.

Our WellBiome health and wellness program: a monthly health stipend, open standing desks, and weekly boot camp and yoga classes on-site.

Apple computer all its fancy accessories

Friendly and open office environment with great colleagues and an intentional culture that drives innovation, passion, collaboration, and fun!

A picture is worth a thousand words. Check out our Instagram @secondgenomelife for a glimpse into our unique team culture.

Company info

Second Genome
Website :

Company Profile
By bringing microbiome science to the discovery and development of therapeutic products, Second Genome has established a pipeline of therapeutic candidates for inflammatory bowel and metabolic diseases. Our development pipeline is fueled by novel technologies for identifying, screening, and scientifically validating product candidates through a comprehensive understanding of host-microbe interaction and the resulting implications in driving disease. Founded on groundbreaking science from Lawrence Berkeley National Laboratory with the support of veteran biotechnology entrepreneurs, our technologies have been validated through partnerships with leading pharmaceutical and nutrition companies, as well as academic and governmental research institutions. The company is backed by investors with a track record of value creation, including Advanced Technology Ventures and Morgenthaler Ventures.

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