Massachusetts General Hospital
Employing Hospital and Department:
Ragon Institute of MGH, MIT, and Harvard
Minimum degree and field of knowledge:
Years experience required:
0 - 2 years experience
The Ragon Institute of MGH, MIT and Harvard located in Kendall Square in Cambridge, MA has an opening in the Allen laboratory ( http://www.ragoninstitute.org/portfolio-item/allen-lab/ ) for a highly motivated postdoctoral fellow to study the role of HIV sequence evolution in the development of broadly neutralizing antibodies.
This position requires a Ph.D. or an M.D. with a background in humoral immunity, evolutionary biology, and/or bioinformatics. Research will focus on elucidating the role that viral evolution and escape from humoral immune responses plays in the development and maturation of broadly neutralizing antibodies to HIV. Efforts will include application of next generation sequencing (NGS) technologies to address these questions and development of advanced comparative genomic tools for the analysis of large viral genomic NGS datasets.
Goals are to understand the role of HIV sequence evolution in the development of broadly neutralizing antibodies and apply this knowledge to design the effective components of an HIV vaccine.
State-of-the-art facilities are available within an exceptionally energetic research setting.
Under the direction of the principal investigator the applicant independently carries out daily activities of the laboratory.
Performs molecular biology and cell-based assays utilizing standard techniques (DNA/RNA extraction and analysis, standard and quantitative PCR, site-directed mutagenesis, neutralization assays, ELISAs)
Next-generation Illumina library construction and sequencing
Bioinformatic analysis of conventional bulk and next-generation sequence data
Develop a dvanced comparative genomic tools for the analysis of large viral genomic NGS datasets
Detailed documentation of the experimental work
A Ph.D. or M.D. with relevant experience in humoral immunity, evolutionary biology, and/or bioinformatics.
Strong candidates will have demonstrated experience in the immunology or virology of infectious diseases and/or experience with NGS analysis and phylogenetic tools.
Candidates must be highly motivated and independent, with the ability to work in a dynamic team environment.
Good organizational skills and excellent attention to detail
Ability to perform as a team member and must have good interpersonal skills
Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.
Partner's Healthcare is acting as an Employment Agency in relation to this vacancy.
Position Type: Full-Time Permanent
Years of Experience Required:
Massachusetts General Hospital
Website : http://www.massgeneral.org/
Since 1811, Massachusetts General Hospital has been committed to delivering standard-setting medical care. Throughout the decades, the hospital has had a consistent commitment to advancing that care through pioneering research and educating future health care professionals.The third oldest general hospital in the United States and the oldest and largest hospital in New England, Mass General continues its tradition of excellence today. Mass General has consistently placed among the top hospitals on the U.S. News & World Report Best Hospitals Honor Roll since the survey began in 1990. In 2015, Mass General was named #1 in the nation based on our quality of care, patient safety and reputation in 16 clinical specialties. In 2013, Mass General was also redesignated a Magnet hospital, the highest honor for nursing excellence awarded by the American Nurses Credentialing Center.