Post Doc Instructions Please do not submit an application to this posting. To apply for this postdoctoral research opportunity, follow the directions below in \u201cApplicant Special Instructions\u201d. Job Type\/Schedule This position is full-time and works approximately 40 hours per week. Department Name\/Job Location This position is in the Department of Internal Medicine, Renal Division. This position is for the Medical School Campus. Essential Functions POSITION SUMMARY: An opportunity is immediately available for a Postdoctoral Research Associate at the Washington University Division of Nephrology. Endoplasmic reticulum (ER) dysfunction and protein misfolding disease is an emerging field. The overall goals of our research are to delineate the molecular mechanisms underlying ER stress-mediated kidney diseases, including nephrotic syndrome (NS), Alport syndrome, autosomal dominant tubulointerstitial kidney disease (ADTKD) and other acquired forms of ER disease, to develop ER stress biomarkers in human patients, and to identify ER stress modulators. (JCI Insight 2(23): e92896 2017; J Am Soc Nephrol. 27: 2974-2982 2016; J Am Soc Nephrol. 24: 1223-1233 2013; J Am Soc Nephrol. 22: 849-858 2011; two patent applications related to the discovery of ER stress biomarkers). The second focus in the laboratory is to study the crosstalk between podocytes and glomerular endothelial cells (GECs) or tubular cells and peritubular capillary ECs in a variety of kidney diseases, including NS and renal fibrosis.\u00a0 We are using cutting-edge research approaches, including stably transfected or knock-down cells, molecular and cell biology, biochemistry, inducible transgenic, conditional knock-out and knock-in mouse models, human iPSCs derived from patients, and state-of-the-art in vitro & in vivo imaging techniques. We also have access to multiple kidney disease consortiums to acquire their genomic data, gene expression, histology from kidney biopsies, and urine samples.\u00a0 The PI\u2019s research has been funded by multiple grants from NIH, the Children\u2019s Discovery Institute, American Society of Nephrology, Doris Duke Charitable Foundation, NEPTUNE etc. and industry. The lab environment is highly supportive and the position will be stable for at least 3-4 years. PRIMARY DUTIES AND RESPONSIBILITIES: Contribute intellectually and experimentally to the initiation and progression of the research projects. Work independently to generate, analyze, and present experimental results. Assist in the preparation of manuscripts and grant applications. Help manage the essential functions of the laboratories.\u00a0 Required Qualifications PhD\/MD in a relevant field is required.\u00a0 Salary Range Base pay commensurate with experience. Department Summary The Washington University Division of Nephrology (https:\/\/renal.wustl.edu) has been ranked top ten by US News & World Report every year since ratings began. The research environment is outstanding. Benefits This position is eligible for full-time benefits. Please visit our website at http:\/\/hr.wustl.edu to view a summary of benefits. Applicant Special Instructions If you are a career-oriented and highly motivated researcher who intends to be productive in the postdoc period and is willing to work hard, please email a CV, a cover letter and the names of three references to: Y. Maggie Chen, MD, PhD Assistant Professor of Medicine Division of Nephrology Washington University School of Medicine Box 8126 660 S. Euclid Avenue St. Louis, MO 63110 Email: firstname.lastname@example.org EOE Statement Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.
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