Postdoctoral Fellow in Chemistry
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John D. McArthur Campus
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A Postdoctoral position is available in the laboratory of Professor Gregg Fields, **MEMBERS ONLY**SIGN UP NOW***. Jupiter, FL, to elucidate roles of matrix metalloproteinases in cancer progression and metastasis.
Remodeling of the extracellular matrix (ECM) is crucial in development and homeostasis, but also has a significant role in disease progression. Mammalian ECM remodeling enzymes include members of the matrix metalloproteinase (MMP) family. MMPs have long been implicated for roles in cancer initiation, tumor growth, and metastasis. MMPs are recognized for their ability to catalyze the hydrolysis of collagen, growth factors, cell surface receptors, and other membrane-bound molecules in physiological and pathological conditions. In addition, MMPs have been found in the cytosol, organelles, and intracellular compartments, and recently several MMPs have been found in the nucleus. However, the mechanisms and roles of MMPs inside the cell are still poorly understood.
We are seeking a highly motivated molecular biologist to join an interdisciplinary team of scientists. Dr. Fieldsâ€™ laboratory is conducting highly interdisciplinary research focused on elucidating novel roles of MMPs in health and disease, with the goal of designing novel cancer progression diagnostics and anti-cancer drugs.
The Postdoctoral Fellow will contribute to the design of biological and biochemical assays targeting MMPs as potential anti-cancer agents with a major focus on bacterial and mammalian protein expression and purification, and visualization/quantification of cell-based protease activity.
Ph.D. in Molecular or Cell Biology from an accredited institution by time of appointment required. Must be a first author on at least 2-3 publications and/or have a strong publication record. Must be independent in the experimental design, solving challenging cloning, purification and cell-based assay problems, and efficient in biochemical assays.Extensive experience in protein design and construction, tissue culture, molecular cloning, bacterial and mammalian protein expression, and biochemical enzyme analysis required. Expertise in using FPLC, PCR, cloning/expression of proteins, and assay development required. Excellent oral and written communication skills required.Background in extracellular matrix biochemistry, proteases of the extracellular matrix; cancer biology and tumor cell biology/signal transduction in a protease field preferred.
$45,000 - $50,000
College or Department:
John D. McArthur Campus - Jupiter
Work Days and Hours:
Special Instructions to Applicant:
This position is open until filled and may close without prior notice. All applicants must apply electronically to the currently posted position on the Office of Human Resources' job website (~~~) by completing the required employment application for this recruitment and submitting the related documents. The site permits the attachment of required/requested documentation. In addition to completing the online application, please upload the following: a cover letter, curriculum vitae, and copies of official transcripts scanned into an electronic format, and contact information for 2-3 references combined into one PDF file by e-mail to: ~~~. Degrees from outside the United States must be validated by an organization belonging to the National Association of Credential Evaluation Service (NACES), with an indication of the documents the evaluation was prepared from (official transcripts, diplomas, dissertation abstracts). The evaluation should be scanned and electronically attached to one's application as with other US-based transcripts. Prior to appointment, the candidate must submit official, sealed transcripts from all institutions where graduate coursework was attempted, whether or not a degree was obtained, as well as an original NACES evaluation, if applicable. Transcripts must be issued to **MEMBERS ONLY**SIGN UP NOW***. not to you as the student. A background check will be required for the candidate selected for this position. This position is subject to funding.Individuals requiring accommodation, please call ~~~. 711
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