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Job Details

Senior Scientist Biochemistry/Bioconjugation

Company name
Pfizer Inc

La Jolla, CA, United States

Employment Type

Chemistry, Sciences, Scientist, Post Doc

Posted on
Apr 23, 2020

Valid Through
Aug 06, 2020

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BioMedicine Design (BMD) is seeking a highly motivated and innovative scientist to join a protein engineering group supporting the Biotherapeutics portfolio of Pfizer, Inc. in La Jolla, CA. Responsibilities will be driving therapeutic innovation through technology development and contributing to the pipeline, including conducting and optimization of reaction, purification, and characterization of bioconjugates of antibodies or fusion proteins with small molecules or imaging agents. In-depth understanding of biochemistry and expertise in complex synthetic and bioconjugation chemistry and separation will be essential to this position.

Role Responsibilities

Integral member of a highly-collaborative team executing on time-sensitive protein engineering projects all the way from antibody/antigen design & generation through protein purification and characterization.

Independently design, conduct, trouble-shoot protein biochemical and conjugation experiments

Evaluate key quality attributes of fusion proteins, antibodies, and bioconjugates

Serve as the subject matter expert for biological assays, biochemical assays and bioconjugation, improve existing processes

Desire to understand underlying biology and mechanism of targets and biologics.

Present results regularly at team meetings and drive data-driven decisions

Perform diligent and timely note-keeping and work process tracking

Basic Qualifications:

PhD in chemistry/biochemistry/chemical biology or a related discipline

Extensive hand-on experience with protein biochemistry and bioconjugation with state-of-the-art knowledge of diverse conjugation methods

Technically proficient in protein engineering tools, including construct design, molecular biology (restriction cloning, Gibson assembly), protein expression in E.coli and mammalian/insect cell systems, protein purification (affinity chromatography, SEC, ion exchange, gravity or chromatography mode) and characterization (SDS-PAGE, RP-HPLC, analytical SEC, and mass spectrometry, in vitro activity).

Knowledge of basic pharmacology principles and drug delivery

Experience with data analysis and presentation software

Excellent written and oral communication skills

The individual should be scientifically creative and driven by a willingness to embrace innovation within drug discovery and an eagerness to challenge and meet aggressive timelines

An innovator with track record in molecular design of biologics, of creative and proactive approach to problem solving, and strong analytical skills.

Strong motivation, passion and commitment to science and engineering of novel entities

Ability and desire to work in an interdisciplinary scientific team and the desire to learn new techniques

The ability to work closely with other group members within teams is essential

Preferred Qualifications:

R&D experience in an industry setting with good understanding of biologic drug development or 2 years of postdoctoral experience

Prior experience in antibody-drug conjugate research

Experience with antibody/protein expression and purification

Training in enzymology

Understanding of biodistribution, metabolism, and modeling tools

Other Job Details:


Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

Company info

Pfizer Inc
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