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Postdoctoral Associate - Structural Biology

Company name
Virginia Tech - Capelluto Laboratory

Location
Blacksburg, VA

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POSTDOCTORAL ASSOCIATE POSITION IN STRUCTURAL BIOLOGY: The Daniel Capelluto’s laboratory is looking for a Postdoctoral Associate candidate for structural biology, specifically in the design of a peptide to be employed to block platelet-cancer cell interactions. The Capelluto’s lab uses a combination of structural, biophysical, cell-based, and computational tools to establish how protein domains signal through membrane lipids. Research Project: The successful candidate will contribute to a project, carried out in collaboration with Virginia Tech cell biologists, chemical engineers, and bioinformaticians, to develop peptides that will be able to bind to specific lipids at the platelet and leukemia cell surfaces to block platelet-leukemia cell interactions. We plan to use NMR and other structural approaches to assess the folding and stability of the peptides followed by their encapsulation to nanoparticles for delivery purposes. Nanocarriers will be evaluated using cell-cell adhesion assays and in endothelial cell-coated microfluidic devices. The research will be conducted in the Capelluto laboratory of the Biocomplexity Institute at Virginia Tech. Our primary technique is solution-state NMR spectroscopy complemented by biophysical techniques, including surface plasmon resonance, circular dichroism, atomic force microscopy, isothermal calorimetry, and dynamic light scattering).

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Virginia Tech - Capelluto Laboratory

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