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Job Details

Postdoctoral Scientist- Pharmacometrics

Company name
Biogen Idec

Location
Cambridge, MA

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\u003Cdiv\u003E\u003Cstrong\u003ESummary\u003C/strong\u003E\u003C/div\u003E\u003Cdiv\u003EThe Clinical Pharmacology \\u0026 Pharmacometrics (CPP) group is seeking for outstanding candidates for a 2-3 years postdoctoral position in pharmacometrics (exposure-response modeling with imaging outcomes). This position offers a unique opportunity to work as part of a multidisciplinary team to facilitate all stages of CNS drug development, and is focused on the application of PK/PD mechanistic modeling and simulation to characterize PK and PD of novel modalities.\u003C/div\u003E\u003Cdiv\u003E\u003Cstrong\u003EJob Description\u003C/strong\u003E\u003C/div\u003E\u003Cdiv\u003EMultiple neurology programs in Biogen are targeted at modifying the natural turnover of harmful proteins. The Clinical Pharmacology and Pharmacometrics (CPP) function develops models relating the exposure (PK) to the time course of target protein. Understanding of and incorporating information for the natural turnover rate of the target proteins in these models is essential for the evaluation of the biological and disease-related activity of our drug candidates.\u003Cbr/\u003EWe are looking for a motivated candidate to become a part of the joint effort between CPP and Biomarker Center of Excellence to integrate model derived knowledge about the target proteins in the existing mechanistic PK-PD models based on early phase clinical data. The methodology developed will be validated with data from a number of drug development programs. Such methodology has not been critically and comprehensively evaluated in the existing literature, so it will represent significant scientific novelty, and can be published extensively. The project scope includes performing hands-on preclinical, translational and clinical modeling tasks using nonlinear mixed effects and physiologically-based modeling techniques to support dose selection, optimization and clinical trial design.\u003Cbr/\u003EThe successful candidate should have a strong interest in developing novel methods and creative problem solving in PK/PD modeling and simulation. This candidate will be an integral part of CPP and work in close collaboration with scientific experts from preclinical and clinical drug development. During this fellowship, this candidate will have a full and diverse immersion in all stages of drug development at the cutting edge of biotechnology, and an opportunity to make an impactful contribution on the development of novel therapeutics in Alzheimer and other neurodegenerative diseases in the discipline of clinical pharmacology and pharmacometrics.\u003Cbr/\u003EThis opening is an ideal opportunity for individuals with quantitative background and affinity to biomedical problems to attain deep specialization and expertise in clinical pharmacology and drug development.\u003C/div\u003E\u003Cdiv\u003E\u003Cstrong\u003EQualifications\u003C/strong\u003E\u003C/div\u003E\u003Cdiv\u003EMust have a doctoral degree in Applied mathematics, Pharmacometrics, Biomedical or Chemical Engineering, Pharmaceutical Sciences, or a closely related discipline. Previous experience in modeling and simulation using PK/PD data with hands-on familiarity in Phoenix WinNonlin, NONMEM, R, Monolix is preferred. Previous experience in CNS biomedical research is preferred, but not required.Team player and effective communicator with the ability to contribute independently. Publication record at conferences and/or peer reviewed journals.\u003C/div\u003E\u003Cdiv\u003E\u003Cstrong\u003EEducation\u003C/strong\u003E\u003C/div\u003E\u003Cdiv\u003ERecent PhD in Pharmacometrics, Applied mathematics, Biomedical or Chemical Engineering, Pharmaceutical Sciences, or a closely related discipline.\u003C/div\u003E\u003Cdiv\u003EAll individuals deserve the right to achieve their full potential. Accordingly, our company welcomes all job applicants, and we strive to provide all employees with equal opportunity for advancement. We will not tolerate any form of discrimination or harassment based on an individual's sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information, or any other basis protected by local government agencies or law.\u003C/div\u003E\u003Cdiv\u003EAs an employer of choice, we strive to:\u003C/div\u003E\u003Cdiv\u003EProvide attractive employment opportunities for diverse candidates at all levels and in all segments of our organization\u003C/div\u003E\u003Cdiv\u003EPursue and maintain relationships with sources of diverse candidates, community organizations, and academic institutions\u003C/div\u003E\u003Cdiv\u003EComply with both the letter and the spirit of all applicable laws and regulations relating to nondiscrimination and affirmative action in employment\u003C/div\u003E\u003Cdiv\u003EVEVRAA Federal Contractor\u003C/div\u003E\u003Cdiv\u003EWe Request Priority Protected Veteran and Disabled Referrals for all of our locations\u003C/div\u003E,datePosted:2018-05-14,employmentType:FULL_TIME,industry:Other,hiringOrganization:{@type:Organization,name:Biogen},identifier:{@type:PropertyValue,name:Biogen,value:33939BR},jobLocation:{@type:Place,address:{@type:PostalAddress,addressCountry:US,streetAddress:225 Binney Street,addressLocality:Cambridge,addressRegion:MA,postalCode:02138}}}

Company info

Biogen Idec
Website : https://www.biogen.com

Company Profile
We measure success by our impact on the patients we serveBiogen, Inc. (previously known as Biogen Idec) is an American global biotechnology company based in Cambridge, Massachusetts, specializing in the discovery, development, and delivery of therapies for the treatment of neurodegenerative, hematologic, and autoimmune diseases to patients worldwide.iogen was founded in 1978 in Geneva[2] by several prominent biologists, including Kenneth Murray of the University of Edinburgh, Phillip Allen Sharp of the Massachusetts Institute of Technology, Walter Gilbert of Harvard (who served as CEO during the start-up phase), Heinz Schaller, University of Heidelberg and Charles Weissmann, University of Zurich (who contributed the first product interferon alpha). Gilbert and Sharp were subsequently honored with Nobel Prizes: Gilbert was recognized in 1980 with the Nobel Prize in Chemistry for his work in understanding DNA sequencing, while Sharp received the Nobel Prize in Physiology or Medicine in 1993 for his discovery of split genes.

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