Brigham and Women's Hospital
We are seeking exceptional candidates for a postdoctoral research fellowship position in the Functional Genetics Laboratory of the Channing Division of Network Medicine who will be responsible for investigating the functional impact of the most important asthma susceptibility genes identified to date by whole genome approaches. Multiple conditional and inducible murine models and in vitro systems necessary to pursue these studies have already been established by our group and are available for immediate use. The Fellow is expected to take a leading role in the development and implementation of this research program, and will be responsible for conducting a variety of in vitro, ex vivo and in vivo studies in this capacity. The position requires comprehensive knowledge and experience in the conduct of molecular genetic studies, including cell culture, transfection, DNA editing, genomic profiling, and murine models of disease.
Key Roles and Responsibilities
The Fellow will be responsible for leading and managing the functional genomics of asthma studies. These activities will include:
Design and perform experiments to elucidate the functional impact of genes, proteins and genetic variants implicated in asthma pathogenesis and severity. This will include, but will not be limited to cell culture (including air-liquid interface), CRISPR-based genetic editing, transfection studies, genomic profiling and murine models of asthma and allergic disease. Facility with both cellular and molecular phenotyping and preparation and interpretation of genomic assays will be expected.
To disseminate the outcomes of the research, including peer-reviewed academic publications of international standing. There is an expectation that the Research Fellow will take lead-authorship in this process.
• To take responsibility for, manage and conduct administrative and management tasks associated with the research program, including maintaining detailed descriptions of experimental protocols, individual experiments, and results; development of tables and figures for presentations, and participating in annual progress report development.
• To oversee the maintenance of mouse lines, primary human cell lines, and other biospecimens collected for the projects.
T o attend weekly laboratory meetings with the PI and laboratory faculty to present work in progress.
To participate fully in the wider research and scholarly activities of the Channing Division of Network Medicine
The fellow will be expected to carry out any additional duties as may reasonably be required within the general scope and level of the post
The appointment is initially for a period of 36 months, supported through two NIH grants. The Research Fellow will work in the Channing Division of Network Medicine Functional Genetics Laboratory, directed by Dr. Xiaobo Zhou. The Research Fellow will report to both Dr. Zhou and the PI of the research project - Dr. Benjamin Raby. The Research Fellow will be expected to observe the laboratory practices and policies set forth by Dr. Zhou in her laboratory, and those of the Channing Division of Network Medicine (CDNM), Brigham and Women's Hospital, and Harvard Medical School.
Successful candidates should have strong foundation in molecular and cell biology, preferably with prior post-doctoral experience in either the development of functional genomic assays, high-throughput cellular phenotyping, or expertise in regulatory genetics and genomics. This position requires strong motivation to work in a dynamic and challenging research area.
Brigham and Women's Hospital is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, sexual orientation, protected veteran status, or on the basis of disability.
Partner's Healthcare is acting as an Employment Agency in relation to this vacancy.
Position Type: Full-Time Permanent
Years of Experience Required:
Brigham and Women's Hospital
Website : http://www.brighamandwomens.org
Boston's Brigham and Women's Hospital (BWH) is an international leader in virtually every area of medicine and has been the site of pioneering breakthroughs that have improved lives around the world. A major teaching hospital of Harvard Medical School, BWH has a legacy of excellence that continues to grow year after year. Brigham and Women’s Health Care – the parent corporation for Brigham and Women’s Hospital, Brigham and Women’s Faulkner Hospital and the Brigham and Women’s Physician Organization – includes 150 outpatient practices with over 1,200 physicians. We serve patients from New England, throughout the United States, and from 120 countries around the world.BWH is an internationally-known referral center for the most complex cases in nearly all areas of medicine. In fact, US News and World Report consistently ranks us among the nation’s top ten hospitals and in the top ten for specific specialty areas that in 2015 include cancer, cardiology and heart surgery, diabetes and endocrinology, geriatrics, gynecology, nephrology, neurology and neurosurgery, orthopedics, pulmonology, and rheumatology. The BWH name is a reflection of our history. In 1980 three of Boston’s oldest and most prestigious Harvard Medical School teaching hospitals - the Peter Bent Brigham Hospital, the Robert Breck Brigham Hospital, and the Boston Hospital for Women – merged to form Brigham and Women’s Hospital. As a national leader in improving health care quality and safety, we have helped to develop some of the industry’s best practices including computerized physician order entry (CPOE) to prevent medication errors. The CPOE is now a nationally-accepted safety practice. The BWH Research Institute (BRI) is one of the most powerful biomedical research institutes in the world and the second largest recipient of National Institutes of Health (NIH) funding among independent hospitals in the United States. With over $640 million in total research funding and over 1,000 principal investigators, BWH has long had great success in research as measured by the number of important discoveries made, the size and scope of its research portfolio and the volume of publications annually.