Postdoctoral Research Associate -natural
Synthetic organic chemist position developing novel methods (e.g. electrochemical- and reagent-mediated oxidations) to create natural product-inspired diversity sets for drug discovery. Research is conducted within the highly collaborative environment of the UNC Center for Integrative Chemical Biology and Drug Discovery, where synthesized compounds will be screened against numerous targets/year. ****1) Perform research in synthetic organic chemistry (70%). The primary duty is to design and carry out experiments leading to the synthesis of novel heterocycles inspired by the motifs present in natural products. The following sub-tasks are associated with this duty: ? Carry out literature searches relevant to the research topic. ? Help in the cleaning, organization, and maintenance of the laboratory and equipment contained therein. ? Be acquainted and up-to-date with laboratory safety protocols and employ them in the course of all work. ? Keep detailed notes and records pertaining to all research work and be comfortable with the required use of electronic notebook software. ? Collecting and interpreting data and using results to drive additional experimental design. 2) Attend and participate in scientific group meetings, departmental seminars, and problem sessions (10%). 3) Contribute to the preparation and submission of reports and publications related to research (15%). 4) Report results at external, field appropriate scientific meetings (5%).
Preferred: ? Strong organic synthesis skills, as evidenced by peer reviewed publications. ? Commitment to safe laboratory practices ? Experience with a wide range of purification techniques (e.g. flash chromatography, HPLC, distillation, etc.) ? Evidence of collaborative research experience ? Experience in the construction of chemical libraries or diversity-oriented synthesis. ? Experience in the construction of heterocyclic molecules. ? Extensive familiarity with NMR acquisition and spectral analysis.Ph. D. in organic chemistry, medicinal chemistry or related discipline
American Recovery & Reinvestment Act Funded: